Biomotors, viral assembly, and RNA nanobiotechnology : current achievements and future directions

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Robland, L., Beasock, D., Afonin, K. A., & Schlick, T. (2022). Biomotors, viral assembly, and RNA nanobiotechnology : current achievements and future directions. Computational And Structural Biotechnology Journal. https://doi.org/doi:10.1016/j.cbsj.2022.11.007
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Description

Graduate, The International Society of RNA Nanotechnology and Nanomedicine (ISRNN) serves to further the development of a wide variety of functional nucleic acids and other related nanotechnology platforms. To aid in the dissemination of the most recent advancements, a biennial discussion focused on biomotors, viral assembly, and RNA nanobiotechnology has been established where international experts in interdisciplinary fields such as structural biology, biophysical chemistry, nanotechnology, cell and cancer biology, and pharmacology share their latest accomplishments and future perspectives. The results summarized here highlight advancements in our understanding of viral biology and the structure-function relationship of frame-shifting elements in genomic viral RNA, improvements in the predictions of SHAPE analysis of 3D RNA structures, and the understanding of dynamic RNA structures through a variety of experimental and computational means. Additionally, recent advances in the drug delivery, vaccine design, nanopore technologies, biomotor and biomachine development, DNA packaging, RNA nanotechnology, and drug delivery are included in this critical review. We emphasize some of the novel accomplishments, major discussion topics, and present current challenges and perspectives of these emerging fields.

Details
Title

Biomotors, viral assembly, and RNA nanobiotechnology : current achievements and future directions

Author(s)

Robland, Lewis
Beasock, Damian
Afonin, Kirill A.
Schlick, Tamar

UNC Charlotte Affiliate Type

Graduate

Extent

1 online resource

Date Created

2022

Genre

articles

Resource Type

text

Abstract

The International Society of RNA Nanotechnology and Nanomedicine (ISRNN) serves to further the development of a wide variety of functional nucleic acids and other related nanotechnology platforms. To aid in the dissemination of the most recent advancements, a biennial discussion focused on biomotors, viral assembly, and RNA nanobiotechnology has been established where international experts in interdisciplinary fields such as structural biology, biophysical chemistry, nanotechnology, cell and cancer biology, and pharmacology share their latest accomplishments and future perspectives. The results summarized here highlight advancements in our understanding of viral biology and the structure-function relationship of frame-shifting elements in genomic viral RNA, improvements in the predictions of SHAPE analysis of 3D RNA structures, and the understanding of dynamic RNA structures through a variety of experimental and computational means. Additionally, recent advances in the drug delivery, vaccine design, nanopore technologies, biomotor and biomachine development, DNA packaging, RNA nanotechnology, and drug delivery are included in this critical review. We emphasize some of the novel accomplishments, major discussion topics, and present current challenges and perspectives of these emerging fields.

Subjects--Topics

Viruses
Nanotechnology

Is Part Of

Computational and structural biotechnology journal

Language

English

Published Version (Please cite this version)

doi:10.1016/j.cbsj.2022.11.007

Publisher's Version

https://doi.org/10.1016/j.csbj.2022.11.007

Rights

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